MS / MD · Obstetrics & Gynaecology

Obstetrics & Gynaecology thesis topics, with the design and feasibility for each

Obstetric data accrues faster than in any other surgical specialty because the labour room runs every day, which tempts residents into samples larger than they can follow up; the difficulty is almost always the neonatal or six-week endpoint rather than the enrolment. Gynaecology theses are slower and usually rest on the OPD, the ultrasound room and the histopathology report, so confirm that your pathology department will report endometrium to the classification you intend to use. Examiners press on gestational age dating, on how comparison groups were allocated in an induction or drug study, and on whether maternal and perinatal outcomes were defined before collection rather than counted afterwards.

Topic register · 48 entries · 8 designs^[6]

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NMC PGMER-2023
NBEMS 180 days / 26 months
UGC 2018 · under 10%
ICMR 2017 · ethics

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Study design

Feasibility in a teaching unit

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Showing 48 of 48 topics

The sample figure on each plate is a planning range read off the design, not a calculated answer. Your own number comes from a calculation against your own assumptions — the difference you would call clinically meaningful, the variability in your setting, the power you want — and it belongs in the synopsis with those assumptions written beside it.

Topic 01 / 48
Link to this entry
Maternal and perinatal outcome in pregnancy with moderate to severe anaemia at term
DesignProspective observationalFeasibilityStraightforward
Primary outcome
Composite of preterm birth, low birth weight and need for maternal transfusion
Collection time
10–12 months
Sample, as a planning figure
roughly 150–220 women, subject to a proper calculation
What your unit must already have
- an antenatal and labour room intake with consistent haemoglobin estimation
- birth weight recorded on a calibrated scale within an hour of delivery
- a neonatal unit that records admissions against the mother's record
What derails it
Haemoglobin is measured on different machines in the OPD, the ward and the labour room, and a difference of one gram between them reclassifies women between your severity bands, so fix one laboratory method for the study value.
Topic 02 / 48
Link to this entry
Intravenous iron sucrose compared with oral ferrous ascorbate in iron deficiency anaemia of the second trimester
DesignRandomised controlledFeasibilityModerate
Primary outcome
Rise in haemoglobin at four weeks from the baseline value
Collection time
12–15 months
Sample, as a planning figure
roughly 40–60 per arm, subject to a proper calculation
What your unit must already have
- a day-care area where infusions can be given with observation
- serum ferritin at baseline to confirm iron deficiency
- CTRI registration before the first woman is enrolled
What derails it
Women in the oral arm take iron irregularly because of nausea and will not admit it, so count returned tablets at each visit rather than asking, otherwise you are comparing an observed infusion with an unknown dose.
Topic 03 / 48
Link to this entry
Second-trimester uterine artery Doppler pulsatility index and subsequent development of preeclampsia
DesignCohortFeasibilityModerate
Primary outcome
Preeclampsia by stated blood pressure and proteinuria criteria after the scan
Collection time
12 months of enrolment with follow-up to delivery
Sample, as a planning figure
roughly 200–300 women allowing for attrition, subject to a proper calculation
What your unit must already have
- a sonologist able to perform uterine artery Doppler to a fixed protocol
- booking before twenty-four weeks for most of the antenatal population
- delivery records retrievable for women who deliver elsewhere
What derails it
Women booked in your OPD often deliver at a nursing home nearer home, and the ones lost are not random, so establish a telephone outcome check at term before enrolment rather than after.
Topic 04 / 48
Link to this entry
Maternal and perinatal outcome in early-onset compared with late-onset preeclampsia
DesignProspective observationalFeasibilityStraightforward
Primary outcome
Composite maternal morbidity and perinatal outcome by onset before or after thirty-four weeks
Collection time
12 months
Sample, as a planning figure
roughly 80–120 per group, subject to a proper calculation
What your unit must already have
- reliable gestational age by early scan or certain dates
- a labour room intake with a substantial hypertensive load
- a neonatal unit willing to share admission outcomes
What derails it
The whole grouping depends on gestational age, and a third of women present without a dating scan and with uncertain periods, so write your dating hierarchy into the protocol and exclude the undatable rather than guessing from fundal height.
Topic 05 / 48
Link to this entry
Pritchard regimen compared with a low-dose magnesium sulphate regimen in eclampsia
DesignComparative interventionalFeasibilityModerate
Primary outcome
Recurrence of convulsions after the loading dose
Collection time
15–18 months
Sample, as a planning figure
roughly 35–50 per arm, subject to a proper calculation
What your unit must already have
- an eclampsia caseload that the unit can actually supply
- serum magnesium estimation or rigorous clinical toxicity monitoring
- an institutional protocol permitting both regimens and CTRI registration
What derails it
Eclampsia numbers fall every year in units with good antenatal coverage, so verify last year's figure from the labour room register; a protocol written for forty per arm on an annual load of thirty will not finish.
Topic 06 / 48
Link to this entry
Spot urine protein-creatinine ratio against twenty-four hour urine protein in hypertensive disorders of pregnancy
DesignDiagnostic accuracyFeasibilityStraightforward
Primary outcome
Sensitivity and specificity of the spot ratio against the twenty-four hour collection as reference
Collection time
10–12 months
Sample, as a planning figure
roughly 120–180 women, subject to a proper calculation
What your unit must already have
- laboratory estimation of urine protein and creatinine on a spot sample
- ward nursing able to supervise a complete twenty-four hour collection
- a stated rule for discarding incomplete collections
What derails it
Twenty-four hour collections are incomplete in a ward where the woman walks to a shared toilet, and an undercollected reference standard makes the spot ratio look falsely positive, so verify completeness by urine creatinine and state how many collections you rejected.
Topic 07 / 48
Link to this entry
Single-step DIPSI test against the seventy-five gram oral glucose tolerance test by IADPSG criteria for gestational diabetes
DesignDiagnostic accuracyFeasibilityStraightforward
Primary outcome
Sensitivity and specificity of the single-step test against the standard tolerance test
Collection time
10–12 months
Sample, as a planning figure
roughly 250–350 women, governed by the expected proportion with gestational diabetes, subject to a proper calculation
What your unit must already have
- laboratory capacity for timed glucose samples on the same women
- an antenatal clinic where women can wait two hours
- a stated interval between the two tests
What derails it
Women will not attend twice for glucose testing, and doing both in one sitting changes the second result, so plan the sequence and interval explicitly rather than improvising per patient.
Topic 08 / 48
Link to this entry
Perinatal outcome in gestational diabetes controlled on medical nutrition therapy compared with those requiring insulin
DesignProspective observationalFeasibilityStraightforward
Primary outcome
Birth weight above the ninetieth centile and neonatal hypoglycaemia
Collection time
12–15 months
Sample, as a planning figure
roughly 60–90 per group, subject to a proper calculation
What your unit must already have
- a dietitian or a standard nutrition advice protocol
- capillary glucose monitoring available at home or weekly in clinic
- neonatal blood glucose measured by protocol after birth
What derails it
The groups differ because one failed diet control, so the insulin group is sicker by definition; say this plainly and do not present the comparison as an effect of insulin.
Topic 09 / 48
Link to this entry
Oral misoprostol compared with intracervical dinoprostone gel for induction of labour at term
DesignRandomised controlledFeasibilityStraightforward
Primary outcome
Induction to delivery interval and vaginal delivery within twenty-four hours
Collection time
12 months
Sample, as a planning figure
roughly 50–70 per arm, subject to a proper calculation
What your unit must already have
- both agents stocked for the full study period with a cold chain for the gel
- continuous labour room monitoring with access to caesarean section
- CTRI registration before the first woman is enrolled
What derails it
Dinoprostone gel needs refrigeration and units often run out or keep stock that has broken the cold chain, so log each batch and its storage or the comparison is against a degraded drug.
Topic 10 / 48
Link to this entry
Transcervical Foley catheter compared with vaginal misoprostol for induction with an unfavourable cervix
DesignComparative interventionalFeasibilityStraightforward
Primary outcome
Change in modified Bishop score at twelve hours and mode of delivery
Collection time
12–15 months
Sample, as a planning figure
roughly 40–60 per arm, subject to a proper calculation
What your unit must already have
- a labour room able to place and monitor a cervical catheter overnight
- Bishop scoring by a consistent small group of observers
- facility for continuous fetal monitoring
What derails it
The Bishop score at twelve hours is recorded by whoever is on duty at night, and inter-observer variation in cervical assessment is wide, so limit scoring to a named few examiners.
Topic 11 / 48
Link to this entry
Transvaginal cervical length and modified Bishop score for prediction of successful induction of labour
DesignDiagnostic accuracyFeasibilityModerate
Primary outcome
Vaginal delivery within twenty-four hours of starting induction
Collection time
12 months
Sample, as a planning figure
roughly 150–200 women, subject to a proper calculation
What your unit must already have
- a transvaginal probe and an operator trained in cervical length measurement
- measurement performed before induction begins
- an induction protocol that does not vary by operator
What derails it
The cervical length must be measured before the first dose and with an empty bladder, and on a busy evening the scan gets done after induction has started, which makes the measurement uninterpretable.
Topic 12 / 48
Link to this entry
Membrane sweeping at thirty-nine weeks and spontaneous onset of labour
DesignRandomised controlledFeasibilityStraightforward
Primary outcome
Spontaneous onset of labour within seven days of the procedure
Collection time
12 months
Sample, as a planning figure
roughly 60–90 per arm, subject to a proper calculation
What your unit must already have
- an antenatal clinic seeing women weekly at term
- a stated sweeping technique performed by a small group of examiners
- CTRI registration before enrolment
What derails it
Women examined at term often go into labour after any vaginal examination, so the control arm must have an equivalent examination without sweeping, or the effect you measure is of being examined.
Topic 13 / 48
Link to this entry
Use of the WHO modified partograph and mode of delivery in low-risk primigravidae in spontaneous labour
DesignProspective observationalFeasibilityStraightforward
Primary outcome
Crossing of the alert and action lines and the eventual mode of delivery
Collection time
10–12 months
Sample, as a planning figure
roughly 200–300 women, subject to a proper calculation
What your unit must already have
- a labour room where partographs are completed contemporaneously
- nursing staff briefed on the plotting intervals
- a clear definition of the onset of the active phase
What derails it
Partographs filled in retrospectively at the end of labour are smooth and useless, so arrange for the graph to be checked by the study team at each ward round rather than collected from the file after delivery.
Topic 14 / 48
Link to this entry
Maternal and neonatal outcome in preterm prelabour rupture of membranes managed expectantly
DesignProspective observationalFeasibilityModerate
Primary outcome
Latency from rupture to delivery and neonatal sepsis by the unit's stated criteria
Collection time
12–15 months
Sample, as a planning figure
roughly 60–90 women, subject to a proper calculation
What your unit must already have
- a neonatal intensive care unit that can support preterm babies
- a written antibiotic and corticosteroid protocol for expectant management
- sterile speculum confirmation of rupture rather than history alone
What derails it
Rupture time is taken from the woman's history and is frequently hours or days out, which directly distorts the latency you are measuring, so record both the reported time and the time of confirmation and analyse from the latter.
Topic 15 / 48
Link to this entry
Mid-trimester transvaginal cervical length and spontaneous preterm birth
DesignCohortFeasibilityModerate
Primary outcome
Spontaneous delivery before thirty-seven completed weeks
Collection time
12 months of enrolment with follow-up to delivery
Sample, as a planning figure
roughly 250–350 women allowing for attrition, subject to a proper calculation
What your unit must already have
- transvaginal scanning between eighteen and twenty-four weeks by a trained operator
- an antenatal population that books early enough
- delivery outcome retrievable including deliveries elsewhere
What derails it
If a short cervix is found you are obliged to act on it, and that treatment changes the outcome you are studying, so state in the protocol what will be offered and analyse those women separately.
Topic 16 / 48
Link to this entry
Nifedipine compared with isoxsuprine for arrest of preterm labour
DesignComparative interventionalFeasibilityStraightforward
Primary outcome
Delay of delivery by at least forty-eight hours from the start of tocolysis
Collection time
12–15 months
Sample, as a planning figure
roughly 35–50 per arm, subject to a proper calculation
What your unit must already have
- both drugs available with maternal pulse and blood pressure monitoring
- a labour room able to distinguish true preterm labour from uterine irritability
- antenatal corticosteroid given to both arms by protocol
What derails it
A sizeable share of women labelled as being in preterm labour were never in established labour, and they stay undelivered in both arms and flatten any difference; insist on documented cervical change before enrolment.
Topic 17 / 48
Link to this entry
Caesarean section rate analysed by the Robson ten-group classification in a teaching hospital
DesignRetrospectiveFeasibilityStraightforward
Primary outcome
Caesarean rate and the relative contribution of each Robson group to the overall rate
Collection time
3–4 months of record review over one to two years
Sample, as a planning figure
roughly 2000–4000 consecutive deliveries, limited by what the period contains
What your unit must already have
- a delivery register recording parity, gestation, presentation, onset of labour and previous caesarean
- an ethics waiver for record review
- a clerk or a digital extract to handle the volume
What derails it
Robson classification needs five variables on every delivery and the register commonly omits onset of labour, which makes a quarter of deliveries unclassifiable, so audit a month of the register for completeness before committing to the design.
Topic 18 / 48
Link to this entry
Outcome of trial of labour after one previous lower segment caesarean section
DesignProspective observationalFeasibilityStraightforward
Primary outcome
Successful vaginal birth, with scar dehiscence and perinatal outcome
Collection time
12–15 months
Sample, as a planning figure
roughly 100–150 women, subject to a proper calculation
What your unit must already have
- an institutional protocol permitting trial of labour with continuous monitoring
- immediate access to theatre and blood
- documentation of the previous operative indication where obtainable
What derails it
Many women arrive without the previous operation notes, so the indication and the type of incision are unknown and including them changes the risk profile of your cohort; decide in advance whether an undocumented previous caesarean qualifies.
Topic 19 / 48
Link to this entry
Single-layer compared with double-layer uterine closure at caesarean section and residual myometrial thickness at six months
DesignComparative interventionalFeasibilityModerate
Primary outcome
Residual myometrial thickness at the scar on transvaginal ultrasound at six months
Collection time
12 months of enrolment with six months of follow-up
Sample, as a planning figure
roughly 40–60 per arm, subject to a proper calculation
What your unit must already have
- a transvaginal probe and an operator trained in scar assessment
- operative notes that record the closure technique reliably
- a six-month recall system for postnatal women
What derails it
Postnatal women do not return at six months unless actively recalled, and those who do are often the ones with symptoms, so build telephone recall and a transport allowance into the protocol from the start.
Topic 20 / 48
Link to this entry
Carbetocin compared with oxytocin for prevention of atonic postpartum haemorrhage at caesarean section
DesignRandomised controlledFeasibilityModerate
Primary outcome
Need for an additional uterotonic within two hours of delivery
Collection time
12–15 months
Sample, as a planning figure
roughly 60–90 per arm, subject to a proper calculation
What your unit must already have
- carbetocin stocked for the full period with the cold chain maintained
- a defined criterion for administering additional uterotonics
- CTRI registration before the first woman is enrolled
What derails it
An additional uterotonic is given on the surgeon's impression of uterine tone, so write the trigger as an observable criterion and have it recorded by the anaesthetist rather than the operating obstetrician.
Topic 21 / 48
Link to this entry
Visual estimation of blood loss at vaginal delivery against measurement with a calibrated collection drape
DesignDiagnostic accuracyFeasibilityStraightforward
Primary outcome
Agreement between visually estimated and drape-measured blood loss, and detection of loss above five hundred millilitres
Collection time
9–12 months
Sample, as a planning figure
roughly 200–300 deliveries, subject to a proper calculation
What your unit must already have
- calibrated collection drapes for the full study period
- the visual estimate recorded by the attending staff before the drape is read
- a delivery volume sufficient for the target
What derails it
The estimate must be written down and handed over before anyone looks at the drape markings, otherwise staff anchor on the measured volume and the agreement you report is manufactured.
Topic 22 / 48
Link to this entry
Maternal near-miss events by WHO criteria in a tertiary obstetric unit: causes and contributing delays
DesignRetrospectiveFeasibilityStraightforward
Primary outcome
Near-miss events per thousand live births with the underlying cause and documented delay category
Collection time
4–5 months of record review over two years
Sample, as a planning figure
roughly 100–200 identified events, limited by what the period contains
What your unit must already have
- case records with laboratory and intensive care documentation sufficient to apply WHO criteria
- the delivery denominator from the labour room register
- an ethics waiver for record review
What derails it
WHO near-miss criteria need specific markers such as transfusion volume and duration of ventilation, and files that do not record them will silently undercount, so pilot the criteria on twenty old files before settling the design.
Topic 23 / 48
Link to this entry
Umbilical artery Doppler indices and perinatal outcome in fetal growth restriction
DesignProspective observationalFeasibilityModerate
Primary outcome
Composite adverse perinatal outcome of neonatal unit admission, low Apgar score or perinatal death
Collection time
12–15 months
Sample, as a planning figure
roughly 80–120 pregnancies, subject to a proper calculation
What your unit must already have
- a colour Doppler machine and a sonologist available for serial scans
- reliable gestational dating to define growth restriction
- neonatal outcomes retrievable against the maternal record
What derails it
Absent or reversed end-diastolic flow obliges immediate delivery, so the worst Doppler findings are followed by iatrogenic preterm birth and the outcome then reflects prematurity, which means gestation at delivery must be reported alongside it.
Topic 24 / 48
Link to this entry
Admission cardiotocography and neonatal outcome at delivery in low-risk labour
DesignDiagnostic accuracyFeasibilityStraightforward
Primary outcome
Sensitivity and specificity of an abnormal admission trace for low Apgar score or neonatal unit admission
Collection time
10–12 months
Sample, as a planning figure
roughly 250–350 women, subject to a proper calculation
What your unit must already have
- working cardiotocographs with paper supply for the whole period
- a single classification system for traces applied by trained observers
- neonatal outcome documented by the paediatric team
What derails it
An abnormal admission trace changes management immediately, so the test alters the outcome it is being judged against; acknowledge this and record every intervention taken on the basis of the trace.
Topic 25 / 48
Link to this entry
First-trimester subclinical hypothyroidism and obstetric outcome
DesignCohortFeasibilityModerate
Primary outcome
Composite of miscarriage, preeclampsia and preterm birth
Collection time
12 months of enrolment with follow-up to delivery
Sample, as a planning figure
roughly 250–400 women allowing for attrition, subject to a proper calculation
What your unit must already have
- thyroid stimulating hormone estimation for all women at booking
- trimester-specific reference ranges agreed with the laboratory
- outcome capture for women delivering outside the institution
What derails it
Women found to be hypothyroid are treated, which is correct but removes the exposure you are studying, so the protocol must state that treated women are followed as a separate group rather than dropped.
Topic 26 / 48
Link to this entry
Perinatal outcome in intrahepatic cholestasis of pregnancy
DesignRetrospectiveFeasibilityModerate
Primary outcome
Preterm birth, meconium-stained liquor and stillbirth among affected pregnancies
Collection time
4–5 months of record review over three years
Sample, as a planning figure
roughly 60–120 archived cases, limited by what the period contains
What your unit must already have
- records with serum bile acid or liver function results to support the diagnosis
- delivery and neonatal outcome in the same file
- an ethics waiver for record review
What derails it
Serum bile acid is not measured in many units, so the diagnosis in old files rests on itching with raised transaminases, and you must state that case definition explicitly instead of implying a biochemical one.
Topic 27 / 48
Link to this entry
Mode of delivery and perinatal outcome in twin pregnancies
DesignRetrospectiveFeasibilityStraightforward
Primary outcome
Perinatal mortality and neonatal unit admission for the first and the second twin
Collection time
3–4 months of record review over three years
Sample, as a planning figure
roughly 120–250 twin deliveries, limited by what the period contains
What your unit must already have
- a delivery register identifying multiple pregnancies
- chorionicity documented where a scan report exists
- an ethics waiver for record review
What derails it
Chorionicity is rarely recorded in files and changes the risk completely, so either restrict the analysis to pregnancies with an early scan report on file or report the proportion in which it was unknown.
Topic 28 / 48
Link to this entry
Routine compared with restrictive episiotomy in primigravidae and perineal outcome
DesignComparative interventionalFeasibilityStraightforward
Primary outcome
Perineal trauma classified by degree of tear and perineal pain at forty-eight hours
Collection time
12 months
Sample, as a planning figure
roughly 60–90 per arm, subject to a proper calculation
What your unit must already have
- labour room staff briefed on a restrictive policy and its indications
- perineal examination by a trained observer immediately after delivery
- a standard analgesia policy for both arms
What derails it
A restrictive policy is abandoned the moment the trace looks worrying or the baby seems large, so record every deviation and its reason, because unmeasured crossover is what will sink the comparison.
Topic 29 / 48
Link to this entry
Expulsion and continuation of the postpartum intrauterine contraceptive device at six months
DesignCohortFeasibilityStraightforward
Primary outcome
Device expulsion or removal within six months of insertion
Collection time
12 months of insertion with six months of follow-up
Sample, as a planning figure
roughly 150–250 women allowing for attrition, subject to a proper calculation
What your unit must already have
- a postpartum family planning service inserting devices routinely
- follow-up at six weeks, three and six months including telephone contact
- ultrasound to confirm position in doubtful cases
What derails it
A woman who has the device removed at a local clinic will report it only if you telephone her, so a study counting only clinic attenders reports a continuation rate that belongs to the attenders and not the cohort.
Topic 30 / 48
Link to this entry
Maternal antecedents of low birth weight at term: a case-control comparison
DesignCase-controlFeasibilityStraightforward
Primary outcome
Association of maternal height, gestational weight gain, anaemia and number of antenatal visits with term low birth weight
Collection time
9–12 months
Sample, as a planning figure
roughly 100–150 cases with one to two controls each, subject to a proper calculation
What your unit must already have
- birth weight measured on a calibrated scale within an hour of delivery
- antenatal records with documented weight gain and haemoglobin
- a control selection rule applied from the same delivery register
What derails it
Antenatal weight gain is only usable if the booking weight was recorded in the first trimester, and most women book later, so define the exposure from a stated gestational window rather than from whatever weights the card happens to hold.
Topic 31 / 48
Link to this entry
Antiphospholipid antibodies and thyroid status in women with recurrent early pregnancy loss compared with women with uncomplicated pregnancy
DesignCase-controlFeasibilityDemanding
Primary outcome
Proportion positive for lupus anticoagulant or anticardiolipin antibody, and proportion with thyroid dysfunction, compared between cases and controls
Collection time
15 months
Sample, as a planning figure
roughly 50–70 cases with an equal number of controls, subject to a proper calculation
What your unit must already have
- laboratory capacity for antiphospholipid antibody testing with a stated method
- a clinic that sees recurrent loss in sufficient numbers
- a clear definition of recurrent loss applied to every case
What derails it
Antiphospholipid antibodies must be repeated after twelve weeks to mean anything, and a single positive result is not a diagnosis, so your timeline must allow for the confirmatory sample on every positive case.
Topic 32 / 48
Link to this entry
Thyroid dysfunction in women with polycystic ovary syndrome diagnosed by Rotterdam criteria
DesignCross-sectionalFeasibilityStraightforward
Primary outcome
Proportion with raised thyroid stimulating hormone, with thyroid peroxidase antibody where available
Collection time
9–12 months
Sample, as a planning figure
roughly 120–180 women, subject to a proper calculation
What your unit must already have
- transvaginal or transabdominal ultrasound for ovarian morphology
- androgen assay or a documented clinical hyperandrogenism assessment
- thyroid function testing in the hospital laboratory
What derails it
Rotterdam criteria need two of three features, and ovarian morphology reported as a 'polycystic appearance' without follicle counts does not satisfy the criterion, so agree a counting protocol with radiology before enrolment.
Topic 33 / 48
Link to this entry
HOMA-IR and anthropometric profile across phenotypes of polycystic ovary syndrome
DesignCross-sectionalFeasibilityModerate
Primary outcome
HOMA-IR value with waist circumference and body mass index by phenotype
Collection time
12 months
Sample, as a planning figure
roughly 100–150 women, subject to a proper calculation
What your unit must already have
- a fasting insulin assay available in the institution
- fasting samples collected reliably in an outpatient setting
- a measuring tape and scale used by one trained observer
What derails it
Fasting insulin is not available in many hospital laboratories and sending it outside makes the cost per patient the limiting factor, so confirm the assay, its method and who pays before the synopsis goes in.
Topic 34 / 48
Link to this entry
Letrozole compared with clomiphene citrate for ovulation induction in polycystic ovary syndrome
DesignRandomised controlledFeasibilityModerate
Primary outcome
Ovulation confirmed by follicular monitoring or mid-luteal progesterone over three treatment cycles
Collection time
15–18 months
Sample, as a planning figure
roughly 40–60 per arm, subject to a proper calculation
What your unit must already have
- follicular monitoring by ultrasound through each cycle
- mid-luteal progesterone or another stated ovulation criterion
- CTRI registration and a male factor work-up to define the population
What derails it
Follicular monitoring requires attendance on specific cycle days and women living far away miss the window, so ovulation ends up unconfirmed in a sizeable fraction; decide now how an unmonitored cycle is classified.
Topic 35 / 48
Link to this entry
Hysterosalpingography against diagnostic laparoscopy with chromopertubation for assessment of tubal patency
DesignDiagnostic accuracyFeasibilityModerate
Primary outcome
Sensitivity and specificity of hysterosalpingography against laparoscopic chromopertubation as reference
Collection time
15 months
Sample, as a planning figure
roughly 60–90 women undergoing both procedures, subject to a proper calculation
What your unit must already have
- radiology support for hysterosalpingography in the proliferative phase
- an operative list for diagnostic laparoscopy within a reasonable interval
- both procedures reported to a fixed template
What derails it
Only women who proceed to laparoscopy have a reference standard, and a normal hysterosalpingogram often ends the work-up, so your sample is weighted towards abnormal films and that selection must be stated.
Topic 36 / 48
Link to this entry
Aetiological profile of couples attending an infertility clinic
DesignCross-sectionalFeasibilityStraightforward
Primary outcome
Distribution of female, male, combined and unexplained factors after a stated work-up
Collection time
10–12 months
Sample, as a planning figure
roughly 150–250 couples, subject to a proper calculation
What your unit must already have
- semen analysis performed in the institution to WHO methodology
- ultrasound and hormonal assessment as part of the routine work-up
- a clinic where the male partner actually attends
What derails it
The male partner frequently does not come, so a study that classifies couples on the woman's findings alone will report almost no male factor; make partner attendance an inclusion criterion and report how many couples that excluded.
Topic 37 / 48
Link to this entry
Abnormal uterine bleeding classified by PALM-COEIN and its correlation with endometrial histopathology
DesignCross-sectionalFeasibilityStraightforward
Primary outcome
Distribution of PALM-COEIN categories with the corresponding endometrial histopathological diagnosis
Collection time
10–12 months
Sample, as a planning figure
roughly 150–220 women, subject to a proper calculation
What your unit must already have
- transvaginal ultrasound for structural assessment
- endometrial sampling by pipelle or curettage in the indicated group
- pathology reporting to a stated endometrial classification
What derails it
PALM-COEIN requires imaging detailed enough to separate adenomyosis from leiomyoma subtypes, and a report that says only 'bulky uterus' cannot be categorised, so agree the reporting template with radiology before you begin.
Topic 38 / 48
Link to this entry
Transvaginal sonographic endometrial thickness against endometrial biopsy in perimenopausal abnormal uterine bleeding
DesignDiagnostic accuracyFeasibilityStraightforward
Primary outcome
Sensitivity and specificity of an endometrial thickness cut-off for detecting endometrial pathology on histology
Collection time
12 months
Sample, as a planning figure
roughly 120–180 women, subject to a proper calculation
What your unit must already have
- transvaginal ultrasound with thickness measured by a consistent technique
- endometrial sampling in all enrolled women
- histopathology reported to an agreed classification
What derails it
Thickness must be measured before sampling and in the same cycle phase where a cycle still exists, and a scan done a fortnight earlier at an outside centre cannot serve as your index test.
Topic 39 / 48
Link to this entry
Levonorgestrel intrauterine system compared with oral norethisterone for ovulatory heavy menstrual bleeding
DesignComparative interventionalFeasibilityModerate
Primary outcome
Pictorial blood loss assessment chart score at six months
Collection time
15–18 months
Sample, as a planning figure
roughly 35–50 per arm, subject to a proper calculation
What your unit must already have
- a supply of the intrauterine system for the study period
- a translated pictorial blood loss chart the woman can complete at home
- ultrasound to exclude structural causes before enrolment
What derails it
The pictorial chart assumes the woman uses the same type of sanitary protection throughout, and a switch from cloth to pads mid-study invalidates her score, so record the method at enrolment and at each visit.
Topic 40 / 48
Link to this entry
Non-descent vaginal hysterectomy compared with abdominal hysterectomy for benign uterine disease
DesignComparative interventionalFeasibilityModerate
Primary outcome
Operative blood loss, operating time and length of postoperative hospital stay
Collection time
15 months
Sample, as a planning figure
roughly 35–50 per arm, subject to a proper calculation
What your unit must already have
- surgeons who perform non-descent vaginal hysterectomy routinely
- a stated upper limit of uterine size for inclusion
- blood loss estimated by a single consistent method in both arms
What derails it
Uterine size decides the route in practice, so unless you apply a written size limit and allocate within it you are comparing small uteri removed vaginally with large ones removed abdominally.
Topic 41 / 48
Link to this entry
Risk of Malignancy Index in adnexal masses against histopathology of the operative specimen
DesignDiagnostic accuracyFeasibilityModerate
Primary outcome
Sensitivity and specificity of the Risk of Malignancy Index for malignancy on histopathology
Collection time
15 months
Sample, as a planning figure
roughly 80–120 operated masses, subject to a proper calculation
What your unit must already have
- CA-125 estimation available in the institution
- ultrasound reported with the specific morphological features the index requires
- histopathology on every operated mass
What derails it
The index needs specific ultrasound features scored the same way every time, and a report describing a 'complex cyst' without stating multilocularity, solid areas or ascites cannot be scored, so fix the template with radiology first.
Topic 42 / 48
Link to this entry
Visual inspection with acetic acid compared with conventional cervical cytology, against colposcopy-directed biopsy
DesignDiagnostic accuracyFeasibilityModerate
Primary outcome
Sensitivity and specificity of each screening test against histopathology of the directed biopsy
Collection time
12–15 months
Sample, as a planning figure
roughly 300–500 women screened, governed by the expected proportion with disease, subject to a proper calculation
What your unit must already have
- a colposcope and a trained colposcopist for the reference standard
- cytology reporting to the Bethesda system
- a gynaecology outpatient clinic able to screen women in numbers
What derails it
Only screen-positive women normally go to colposcopy, which makes sensitivity uninterpretable, so a defined sample of screen-negative women must also be biopsied and the protocol must say how they are chosen.
Topic 43 / 48
Link to this entry
Single-dose methotrexate for unruptured ectopic pregnancy: treatment success and features associated with failure
DesignProspective observationalFeasibilityModerate
Primary outcome
Resolution without surgery, defined by a stated fall in serum beta human chorionic gonadotrophin
Collection time
15–18 months
Sample, as a planning figure
roughly 40–60 women, subject to a proper calculation
What your unit must already have
- serial quantitative beta human chorionic gonadotrophin assay with quick turnaround
- transvaginal ultrasound for size and cardiac activity
- a protocol permitting medical management with immediate surgical backup
What derails it
Follow-up needs repeated assays on days four and seven and weekly thereafter, and a woman who is pain-free will not come back for a blood test, so build in active recall and classify defaulters by a rule written in advance.
Topic 44 / 48
Link to this entry
Outcome of medical termination of pregnancy with mifepristone and misoprostol up to nine weeks
DesignProspective observationalFeasibilityStraightforward
Primary outcome
Complete abortion without surgical evacuation, confirmed clinically and by ultrasound at two weeks
Collection time
10–12 months
Sample, as a planning figure
roughly 150–220 women, subject to a proper calculation
What your unit must already have
- a registered termination service with the required documentation
- ultrasound for dating before and for confirmation after
- a follow-up visit at two weeks with telephone backup
What derails it
Gestational age by dates is commonly over- or under-stated and it decides eligibility, so dating must be by ultrasound in every case, with the reported dates kept separately for comparison.
Topic 45 / 48
Link to this entry
Vaginal hysterectomy with pelvic floor repair for pelvic organ prolapse: POP-Q stage and symptom outcome at six months
DesignProspective observationalFeasibilityStraightforward
Primary outcome
POP-Q stage at six months compared with the preoperative stage, with a prolapse symptom score
Collection time
12–15 months
Sample, as a planning figure
roughly 50–70 women, subject to a proper calculation
What your unit must already have
- POP-Q measurement with a graduated device by a trained examiner
- a prolapse operative list with consistent numbers
- a six-month follow-up with examination
What derails it
POP-Q must be measured at maximum Valsalva in a stated position, and a supine examination in a woman who cannot strain will understage her, so fix the position and the straining instruction for preoperative and postoperative assessment alike.
Topic 46 / 48
Link to this entry
Urinary incontinence among parous women attending a gynaecology outpatient clinic, assessed by the ICIQ-UI Short Form
DesignCross-sectionalFeasibilityStraightforward
Primary outcome
Proportion reporting incontinence with ICIQ-UI Short Form score and symptom type
Collection time
8–10 months
Sample, as a planning figure
roughly 300–450 women, subject to a proper calculation
What your unit must already have
- a validated translation of the ICIQ-UI Short Form in the local language
- a private space in the outpatient area for the interview
- a referral pathway for women who screen positive
What derails it
Women do not volunteer these symptoms to a resident in a crowded queue, so the interview must be conducted privately by a consistent interviewer or your proportion will reflect the setting rather than the symptom.
Topic 47 / 48
Link to this entry
Clinical presentation and laparoscopic staging of endometriosis by the revised ASRM score
DesignCross-sectionalFeasibilityModerate
Primary outcome
Revised ASRM stage at laparoscopy with symptom severity on a visual analogue scale
Collection time
15–18 months
Sample, as a planning figure
roughly 50–80 women undergoing laparoscopy, subject to a proper calculation
What your unit must already have
- diagnostic laparoscopy performed for pain and infertility in reasonable numbers
- a surgeon willing to complete the scoring sheet at the time of surgery
- histological confirmation of excised or biopsied lesions
What derails it
The ASRM score must be filled in theatre with the lesions in view; reconstructing it the next day from the operation note produces a stage nobody can defend at viva.
Topic 48 / 48
Link to this entry
Rhesus-negative pregnancies and documented anti-D immunoglobulin prophylaxis: an audit of practice
DesignRetrospectiveFeasibilityStraightforward
Primary outcome
Proportion of eligible women with documented anti-D administration at the correct indication and time
Collection time
3–4 months of record review over two years
Sample, as a planning figure
roughly 200–400 rhesus-negative pregnancies, limited by what the period contains
What your unit must already have
- blood group recorded for all antenatal women in a searchable register
- pharmacy or ward records of anti-D issue
- an ethics waiver for record review
What derails it
Anti-D given in the labour room is often documented only in the nursing notes and not in the case sheet, so reconcile pharmacy issue records with the files or you will report a failure of documentation as a failure of care.

The designs

What each design commits you to

The designs in this Obstetrics & Gynaecology register

The design is not a label on the title; it decides your ethics route, your timetable and the test that answers your primary question. Only the designs that appear above are explained here.

Cross-sectional
6 topics
One contact per participant. Usually the quickest to complete, and the design most often chosen when time is short.
Prospective observational
10 topics
Participants are followed after enrolment without allocating an intervention. Ethics approval must precede the first enrolment.
Retrospective
5 topics
Existing records only. Faster, but limited by what was recorded, and a waiver of consent is normally sought from the ethics committee.
Comparative interventional
7 topics
Two or more arms compared. Ethics scrutiny is heavier, and the protocol must state how allocation is handled.
Randomised controlled
5 topics
Allocation is randomised. Prospective interventional studies are registered with the Clinical Trials Registry of India before the first participant is enrolled.
Diagnostic accuracy
9 topics
An index test measured against a reference standard. The sample size depends on the expected sensitivity or specificity and the prevalence in your setting.
Case-control
2 topics
Cases and controls compared for prior exposure. Control selection is where these are most often criticised.
Cohort
4 topics
A defined group followed over time. Attrition is the usual threat, so plan for it in the sample size.

What the feasibility mark means

A judgement about a typical teaching unit, not about yours. Confirm the volume, the equipment and the co-operation a topic needs before your synopsis goes in, because after that the timetable stops being negotiable^[2].

Straightforward
27 topics
Achievable in most teaching units with routine caseload and no equipment beyond what is already in use.
Moderate
20 topics
Achievable, but needs either a specific piece of equipment, a collaborating department, or a caseload you should confirm before committing.
Demanding
1 topic
Only take this on if your unit already has the volume, the equipment and the co-operation it needs. Confirm all three before your synopsis goes in.

Next steps

Before you commit to one

What to do with a topic you like

Three steps, in this order. None of them is us: the first is arithmetic, the second is your guide, the third is a search only you can run.

Do the arithmetic
The figure on each plate is a planning range, not an answer. Put your own assumptions — the difference you would call clinically meaningful, the variability you expect, the power you want — into the free sample size calculator, then divide the result by the eligible patients your unit sees in a month and see whether the months you have left permit it.
Take it to your guide
Nothing on this page is approved by anybody. Your guide and your department decide what is feasible in your unit, and your ethics committee decides whether it may start — before the first participant, not before the analysis^[5]. Where your university ordinance is stricter than anything here, the ordinance wins^[1].
Run the search yourself
We make no claim that any question here is novel, under-studied or a gap, because that depends on a literature search run today in your own field. Read what the search returns before you write the introduction, and be ready to say why the question is worth asking in your setting.

What a thesis in this field has to satisfy — the obligations, the statistics and the questions residents ask first — is set out on the Obstetrics & Gynaecology page. Other specialties are in the topic bank index, and the method is worked through in the guides.

Undertakings

Mechanisms, not promises

What protects your draft, and who owns the work

Each line below is a mechanism this platform implements or a published instrument it is built around. None of them is a guarantee, and we are affiliated with no regulator or university.

Protection of your work

Row-level security
Every table enforces row-level access. You read your own record, and nothing else.
View-only streaming
Drafts are streamed to you through an authenticated route, not handed over as a file.
Watermarked to you
Every page you read carries your own name and email across it.
Download gated
The final file unlocks when the fee is settled in full, and not before.
Mumbai region · DPDP 2023
Your record and your documents are held in the Mumbai region, so India's Digital Personal Data Protection Act 2023 applies to them.
Anonymised data only
We accept no patient identifiers. An NDA is available on request.

How this works

Instruments we work to

NMC PGMER-2023
The thesis obligations set out in the postgraduate medical education regulations.
NBEMS
DNB and DrNB protocol and thesis timelines, and the page limit, as published.
UGC 2018 · <10%
The academic integrity convention we work to on every draft.
ICMJE · Vancouver
Authorship criteria and reference style, applied as published.
No affiliation
We work to these published instruments. We are affiliated to none of the bodies that issue them.

How this works

Authorship and the uniqueness check

Sole author
Mentoring, editing, statistics and compliance. You remain the sole author of your thesis.
Not ghostwriting
We will not write your thesis for you, and we will not be named in it.
MDSoftune
Word-level uniqueness checking, built with REDENN Informatics Inc., Canada.
Every version
Each draft is checked word by word before your university sees it.

How this works

MDThesis is an independent academic mentorship practice. It is not affiliated with, endorsed by, or acting for the NMC, NBEMS, UGC or any university.

Free feasibility call

Tell us where your thesis stands. A senior doctor will tell you what to do next.

A senior doctor replies within one working day. No obligation. MD, MS, DNB, DrNB, DM, MCh, MDS and international programmes.

Request for a feasibility call

No obligation

Reply within one working day · No obligation · Your details are not shared

Prefer to write to us first? Contact the practice. We mentor and edit; you remain the sole author of your thesis.

References

[1]
Post Graduate Medical Education Regulations, 2023, National Medical Commission. In force 1 January 2024. Thesis requirements at Regulation 5.2. nmc.org.in
[2]
DNB and DrNB thesis guidelines, National Board of Examinations in Medical Sciences. Protocol within 180 days of joining for three-year courses and 90 days for the two-year post-diploma DNB; research study complete by 24 months; thesis by 26 months; 80-page limit inclusive of certificates and annexures. natboard.edu.in
[5]
National Ethical Guidelines for Biomedical and Health Research Involving Human Participants, 2017, Indian Council of Medical Research. Ethics approval precedes data collection. icmr.gov.in
[6]
Counts of specialties, tracked stages, supported currencies and supported countries are structural facts of this platform, read from its own configuration rather than from a claim.

Document: Topic bank — Obstetrics & Gynaecology · Revision 1 · Last reviewed 10 SEPT 2026

Issued by MDThesis, a brand of REDENN Informatics Private Limited

Obstetrics & Gynaecology thesis topics, with the design and feasibility for eachObstetrics & Gynaecology thesis topics, with the design and feasibility for each

Maternal and perinatal outcome in pregnancy with moderate to severe anaemia at term

Intravenous iron sucrose compared with oral ferrous ascorbate in iron deficiency anaemia of the second trimester

Second-trimester uterine artery Doppler pulsatility index and subsequent development of preeclampsia

Maternal and perinatal outcome in early-onset compared with late-onset preeclampsia

Pritchard regimen compared with a low-dose magnesium sulphate regimen in eclampsia

Spot urine protein-creatinine ratio against twenty-four hour urine protein in hypertensive disorders of pregnancy

Single-step DIPSI test against the seventy-five gram oral glucose tolerance test by IADPSG criteria for gestational diabetes

Perinatal outcome in gestational diabetes controlled on medical nutrition therapy compared with those requiring insulin

Oral misoprostol compared with intracervical dinoprostone gel for induction of labour at term

Transcervical Foley catheter compared with vaginal misoprostol for induction with an unfavourable cervix

Transvaginal cervical length and modified Bishop score for prediction of successful induction of labour

Membrane sweeping at thirty-nine weeks and spontaneous onset of labour

Use of the WHO modified partograph and mode of delivery in low-risk primigravidae in spontaneous labour

Maternal and neonatal outcome in preterm prelabour rupture of membranes managed expectantly

Mid-trimester transvaginal cervical length and spontaneous preterm birth

Nifedipine compared with isoxsuprine for arrest of preterm labour

Caesarean section rate analysed by the Robson ten-group classification in a teaching hospital

Outcome of trial of labour after one previous lower segment caesarean section

Single-layer compared with double-layer uterine closure at caesarean section and residual myometrial thickness at six months

Carbetocin compared with oxytocin for prevention of atonic postpartum haemorrhage at caesarean section

Visual estimation of blood loss at vaginal delivery against measurement with a calibrated collection drape

Maternal near-miss events by WHO criteria in a tertiary obstetric unit: causes and contributing delays

Umbilical artery Doppler indices and perinatal outcome in fetal growth restriction

Admission cardiotocography and neonatal outcome at delivery in low-risk labour

First-trimester subclinical hypothyroidism and obstetric outcome

Perinatal outcome in intrahepatic cholestasis of pregnancy

Mode of delivery and perinatal outcome in twin pregnancies

Routine compared with restrictive episiotomy in primigravidae and perineal outcome

Expulsion and continuation of the postpartum intrauterine contraceptive device at six months

Maternal antecedents of low birth weight at term: a case-control comparison

Antiphospholipid antibodies and thyroid status in women with recurrent early pregnancy loss compared with women with uncomplicated pregnancy

Thyroid dysfunction in women with polycystic ovary syndrome diagnosed by Rotterdam criteria

HOMA-IR and anthropometric profile across phenotypes of polycystic ovary syndrome

Letrozole compared with clomiphene citrate for ovulation induction in polycystic ovary syndrome

Hysterosalpingography against diagnostic laparoscopy with chromopertubation for assessment of tubal patency

Aetiological profile of couples attending an infertility clinic

Abnormal uterine bleeding classified by PALM-COEIN and its correlation with endometrial histopathology

Transvaginal sonographic endometrial thickness against endometrial biopsy in perimenopausal abnormal uterine bleeding

Levonorgestrel intrauterine system compared with oral norethisterone for ovulatory heavy menstrual bleeding

Non-descent vaginal hysterectomy compared with abdominal hysterectomy for benign uterine disease

Risk of Malignancy Index in adnexal masses against histopathology of the operative specimen

Visual inspection with acetic acid compared with conventional cervical cytology, against colposcopy-directed biopsy

Single-dose methotrexate for unruptured ectopic pregnancy: treatment success and features associated with failure

Outcome of medical termination of pregnancy with mifepristone and misoprostol up to nine weeks

Vaginal hysterectomy with pelvic floor repair for pelvic organ prolapse: POP-Q stage and symptom outcome at six months

Urinary incontinence among parous women attending a gynaecology outpatient clinic, assessed by the ICIQ-UI Short Form

Clinical presentation and laparoscopic staging of endometriosis by the revised ASRM score

Rhesus-negative pregnancies and documented anti-D immunoglobulin prophylaxis: an audit of practice

What the feasibility mark means

Tell us where your thesis stands. A senior doctor will tell you what to do next.

Obstetrics & Gynaecology thesis topics, with the design and feasibility for each